Success Rates

Understanding IVF Success Rates

There are so many confusing parameters when patients look for clinical success with In Vitro Fertilization. When we developed the original outcome reporting in 1984-85 it was meant to give patients accurate information about live births with IVF. This data was to be in a simple format and protected by outside audit for accuracy. Today the SART CDC report has become so complex, it is hard for even the IVF doctors to follow. In looking at our success at CFP or any other center, we follow a process of review of the annual report.

Because nearly all IVF cycles do not end in a fresh embryo transfer-looking at clinical live birth rates per stimulated cycle is confusing. Instead, focusing on live birth outcome based on a frozen embryo transfer cycle will give an accurate estimation of a clinics success with IVF. Another way to judge clinical success is to look at the live birth outcome with donor eggs. This is a good testament to the center’s IVF laboratory quality. In Egg donor cycles, age of the egg is consistent across the IVF world and live birth outcome with single embryo transfer is a good estimate of a center’s IVF laboratory quality.

“The best way to understand your odds of success with IVF is to meet and talk about your specific clinical issues and get an accurate estimate of your individual situation before starting treatment.”

PGT-A or embryo genetic testing at the blast stage is utilized more and more. In fact in CFP’s last report to SART/CDC for 2017, 75% of IVF cycles utilized PGT-A for embryo selection. In reviewing this technology at CFP, age of the egg correlates highly with normal blastocyst genetics. As the age of the egg increases the number of genetically normal blastocysts decreases. In a recent review of our 2018 genetic data the following was seen from one of our genetic testing laboratories. Ovation Genetics is a national laboratory that does the DNA testing on cells that we send from the blastocyst stage embryo before freezing the blastocyst. The chart below compares our result at CFP in relation to the national results seen at Ovation lab.

Rate of genetically normal blastocysts

AgeCFPOvation National Results
Egg Donor62%61%
<35 y/o60%56%
35-37y/o48%48%
38-40 y/o38%34%
41-42 y/o24%20%
>43 y/o10%12%

Thus couples utilizing PGT-A can understand what the odds of genetically normal embryos based on age of the egg, can be expected.

The best way to understand your odds of success with IVF is to meet and talk about your specific clinical issues and get an accurate estimate of your individual situation before starting treatment.

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